Pestilence - Poison Cloud Nimiod

Info: I took the Catalysers i had not the ones that are necessarily the best, Fire rate is most important for spreading slime everywhere and getting lots of additional hits.

Im still testing if the perk deadly dose or corrosive bile is better, but this version already got me to abyss level 73 without much struggle and if I hadn't died to stupidity probably at least a couple floors more.

One could exchange the primary ability for the chain lighting type one, but spores just fit the Vibe I was going for way better and it didn't feel any worse as the high attack rate keeps the poison stacks up anyways.

For Gameplay loop just spread your notes around when you get a group of enemies and try to stay in the air as much as possible: Essentially playing flappy bird... a lot.
Against bosses wait for them to exit invincible state first then ult and hold fire. while staying in the air to dodge attacks.
You can use the slam attack once its around 30+ stacks to get a nice AoE field and a lot of extra damage ticks against bosses.
Other then that use your teleport to dodge attacks and spread a instant damage through connected nodes.
You should get your Ult back fast enough so don't hesitate to use it.

(A different Nature would probably be best, but this was all I had available for now)